Exosome Therapy and you.

What are Exomes and why are they an important factor to my Stem Cell Therapy?

As researchers from Oxford to Scripps have now concluded, it’s the exosomes stem cells release, rather than the cells themselves, that impart the regenerative benefit. The Mariposa Medispa has spent much time and effort in finding out a way to further proliferate out Stem Cell Therapy programs.

Exosomes are being described as the ‘regenerative essence’ of stem cells. Exosome therapy would avoid all the controversy of a therapy based on live stem cells and yet harness a natural regenerative capability from stem cells.

Tellingly, some biotech stocks established back in the early 2000s as stem cell companies have shifted their focus to exosome research.

Exosomes could be harvested from stem cells can then purified as a proper therapeutic product to be administered by injection or infusion.

Exosomes should be a simpler, safer, lower cost, more easily stored and transported, augment the stem cells.

Critically, exosomes are inherently very safe. Exosomes cannot replicate; they cannot transform into malignant cells or other harmful cell types; they are less likely to trigger an immunogenic response; they cannot be infected with virus.

As a further demonstration of their safety, blood plasma contains high concentrations of unmatched exosomes, and blood transfusions have been carried out in hospitals for decades.

And exosomes should have an efficacy advantage, too. Being much smaller than whole cells, exosomes can circulate much more easily through the body to reach sites of injury or disease and trigger healing.

Early academic clinical studies are starting to prove exosomes’ potential. A recent placebo-controlled trial on 40 patients with advanced chronic kidney disease showed that the patients receiving exosomes saw enhanced kidney function at 12 months after treatment and no adverse events in the treatment group.

Exosomes have multiple shots on goal to drive regeneration

Exosomes administered to patients could exert their regenerative effects in a number of ways – giving treatment by exosomes multiple shots at goal.

Some degeneration, such as Parkinson’s Disease, is due to a loss of specialized cells over time. Struggling cells that take up exosomes can be rescued from programmed cell death (apoptosis), and restored to health, thanks to the regenerative genetic material and the protein and lipid cellular building blocks that the exosome delivers.

Degeneration with age has also been associated with an increase in senescence cells. Senescent cells are like ‘zombie cells’ that don’t undergo normal clearance yet cannot divide and proliferate to generate new tissue.